Archive for août 2014

La Artemisia annua cura la fiebre del dengue

août 24, 2014

La Artemisia de Luxemburgo hace milagros en Vanuatu

En los años de 1970 había sólo nueve países donde existía la fiebre del dengue, pero ahora la cantidad está cercana a los 60. Para 2010, se cree que la fiebre del dengue infecta entre 50 y 100 millones de personas anuales, en todo el mundo, con infecciones con peligro de vida para 500 mil. No existe una cura ni un verdadero tratamiento. Un gran brote de fiebre del dengue ocurrió en Vanuatu en 2014, con varios cientos de casos. Una mujer en Vanuatu fue infectada por este virus. La infección fue clasificada como dengue por los análisis clínicos en el hospital donde permaneció una semana. Ella afirma haberse recuperado después de haber bebido una infusión de Artemisia annua. El origen de la hierba era Luxemburgo.
Más tarde varios de sus parientes sufrieron los mismos síntomas y todos se curaron en pocos días después de beber el té de Artemisia annua. Las autoridades de salud confirmaron que esas personas estaban infectadas con el virus del dengue. Este es el primer informe in vivo sobre la eficiencia de la Artemisia annua contra el dengue. Por supuesto que necesita ser confirmado por medio de ensayos clínicos de acuerdo con el protocolo de la OMS.
Una búsqueda en la literatura científica revela que varias plantas fueron estudiadas en Colombia para determinar su efecto inhibitorio sobre el virus de la fiebre amarilla que es el mismo tipo de Flavivirus que el dengue. El aceite esencial de la Artemisia vulgaris , lo mismo que varias otras plantas, parecen conducir a una inactivación directa del virus. (R. Meneses et al, Annals Clin Microbiol Antimicrobials, 2009, 8:8)
Los flavonoides parecen jugar un gran papel en la actividad antiviral contra el virus del dengue. En un estudio de Malasia (K. Zandi et al., Virology Journal, 201118 :560), la quercetina fue 5 veces más eficiente que otros flavonoides como el naringin, daidze, hespertin. La quercetiba mostró acción tanto terapéutica como profiláctica.
¿Quiénes quieren participar en ensayos clínicos con la hierba Artemisia? Podemos ofrecer libre de costo Artemisia annua de diferentes orígenes; A. afra; A. absinthium; . A. herba alba; otras muestras del mismo genus Asteraceae. Hay disponible detallada información analítica para la mayoría de estas plantas.
Los interesados en obtener las muestras por favor contactarse con nosotros a lutgenp@gms.lu

Publicités

Pinenes: the key of milk’s antimalarial properties?

août 24, 2014

Among the flavonoids and essential oils present in Artemisia annua alpha-pinene has by far the lowest IC50 against Plasmodium falciparum in vitro (PJ Weathers et al., Industrial Crops and Products, 2014, in press). This is confirmed by a research team at the Teikyo University in Tokyo Ryuichi Fujisaki et al, Mar 2012)
A French INRA study found that the most abundant monoterpenes (essential oils) in milk from cows grazing natural diversified pasture were alpha-pinene, beta-pinene and limonene (G Tornambé et al., J Dairy Sci 2006, 89-6, 2309-19) A paper published by another French research team (E.Serrano et al., J Animal and Feed Sciences, 16,2007. 168-179) shows that muscle, fatty tissues and milk are very rich in alpha- and beta-pinene, not only when the cattle are fed extra doses of essential oils, but also in standard milk.

In human volunteers for alpha-pinene absorbed by inhalation only 0.001% is eliminated by urine .The main part accumulates in adipose tissues and is released progressively into blood (AA Falk et al., Scand J Work Envir Health, 1990, 16, 372-78) Terpene content for milk samples is characterized by the same terpenes as those added to food. The terpenes appear to be transferred unaltered into the milk. Volatile terpenes in essential oils, which could influence milk flavor, are transferred into milk via both gastrointestinal and respiratory exposure. Most of it is probably absorbed by inhalation of pinenes emitted by plants or trees. Among all monoterpenes emitted by trees alpha-pinene has on the average the highest percentage (Sophie Moukthar, Thèse de doctorat, 205, Institut Polytechnique de Toulouse). Primary agents of the tree’s defense are monoterpenes, aromatic molecules such as pinenes.

Pinenes and limonene from Artemisia.arborescens also display antiviral properties by inactivating viruses and inhibiting cell-to-cell diffusion (Barbara Adorjan, Diplomarbeit, Universität Wien). They increase the activity of human natural killer cells (Q Li et al., J Biol Regul Homeost Agents, 2010, 24, 157-65). The Japanese call it a forest bathing trip. Pinenes have strong antimicrobial properties (AM Leite et al., Rev Bras de Ciencias Farmaceuticas, 43, 2007). These molecules also have immunostimulating, anti-inflammatory and gastroprotective properties (DK Lima et al., J Ethnopharmacology), 142, 2012, 274-282).

Herbal Artemisia cures dengue!

août 7, 2014

In the 1970s, there were only about nine countries where dengue fever existed but now the number is closer to 60. As of 2010 dengue fever is believed to infect 50 to 100 million people worldwide per year with 1/2 million life-threatening infections There is no cure and no real treatment,
A major dengue fever outbreak took place in Vanuatu in 2014, with several hundred cases. A female person living in Vanuata was infected by this virus. The infection was classified as dengue by clinical analysis in the hospital where she spent a week. She claims to have recovered after drinking Artemisia annua infusion (origin of the herb : Luxembourg). Subsequently several of her relatives suffered from the same symptoms and were all cured in a few days after tea A annua consumption. The Health Authorities confirm that these people were infected by the dengue virus.
This is the first in vivo report on the efficiency of Artemisia annua against dengue. It needs of course to be confirmed by clinical trials in accordance with the WHO protocol.
A literature search shows that several plants were studied in Colombia for their inhibitory effect against the yellow fever virus which is of the same Flavivirus genus as dengue. Essential oil from Artemisia vulgaris like several other plants seems to lead to a direct virus inactivation (R Meneses et al., Annals Clin Microbiol Antimicrobials, 2009, 8 :8)
Flavonoids seem to play a major antiviral activity against dengue virus. In a study from Malaysia (K Zandi et al., Virology Journal, 201118 :560), quercetin was 5 times more efficient than other flavonoids like naringin, daidzein, hesperitin. Quercetin showed prophylactic as well as therapeutic action.
Who would like to participate in clinical trials with Artemisia herb ? We can offer charge free A. annua of different origins, A. afra, A. absinthium, A herba alba and other samples from the same Asteraceae genus. For most of these plants detailed analytical data are available.
Pierre Lutgen
7 Aug 2014

Comment submitted by Marc Vanacker
07/08/2014
Dengue and quercetin
The strong therapeutic action you describe might well be related to glutathione (GSH). Depletion of this powerful antioxidant is a common result of viral infection. The administration of exogenous GSH may reverse all the pathological changes of dengue infection (J Wang et al., PloS ONE 8.1 2012), especially in the liver where virus replication takes place.
Among flavonoids quercetin is one of the most powerful antioxidants. It may compensate for glutathione depletion and even stimulate its production or work in synergy with it.
In malaria glutathione and quercetin inhibit the hemozoin synthesis and thus the detoxification of heme generated by Plasmodium.