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L’antimalaria efficace mais interdit

octobre 30, 2017

Olivier Rogeau
Du LeVif/l’Express du 27/10/17
Remède naturel efficace et bon marché pour prévenir et soigner la malaria, l’artemisia fait une percée spectaculaire en Afrique. Mais l’OMS déconseille l’emploi de cette plante médicinale et la Belgique l’interdit. Serait-elle dangereuse ? Ou menace- t-elle le business des médicaments officiels antipaludéens ?
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Plantation d’artemisia annua au Sénégal. Les plantations de recherche et de production se multiplient en Afrique et ailleurs. © Forget Patrick/photo news
Cela ressemble à une scène récurrente des aventures d’Astérix : la distribution de potion magique. Sauf que nous ne sommes pas chez les Gaulois d’Armorique en 50 avant J.-C., mais chez les Congolais du Maniema aujourd’hui. Et que la composition de la  » potion magique  » consommée par les villageois du coin n’est pas un secret jalousement gardé : c’est une infusion d’artemisia annua (armoise annuelle), une herbe médicinale utilisée en Chine depuis deux mille ans pour prévenir et soigner la malaria. Les plantations de recherche et de production se multiplient en Afrique et ailleurs, comme le raconte le film-documentaire Malaria Business présenté ces jours-ci, en avant-première, en salles à Bruxelles, en Wallonie et à Paris, avant d’être diffusé prochainement sur la Une (RTBF).
Son auteur, le réalisateur belge Bernard Crutzen, a sillonné la planète, de la province du Maniema (RDC) à la Guyane française, du Sénégal à Genève, siège de l’Organisation mondiale de la santé (OMS). Il s’est rendu compte que le paludisme est en chute libre dans les villages où on plante et utilise l’artemisia annua ou sa  » cousine  » africaine, l’artemisia afra. Il fait état d’études scientifiques et médicales conduites en Afrique, aux Etats-Unis et en Europe qui confirment les vertus thérapeutiques de ces plantes consommées sous forme de tisanes, de poudres ou de cachets d’extraits naturels. Mais il tente surtout de comprendre pourquoi l’OMS déconseille d’y recourir.  » Des médecins africains et des laboratoires universitaires voudraient lancer une étude à grande échelle afin de valider les recherches déjà entreprises, signale-t-il. Mais ils ne sont pas soutenus par les grandes institutions publiques et privées.  »
Nouvelles épidémies
Les pays du Sud restent pourtant confrontés à un défi sanitaire majeur : dans le monde, un enfant meurt toutes les deux minutes de la malaria, cette infection parasitaire transmise par un moustique anophèle femelle lui-même contaminé.  » Trois crises avant l’âge de 5 ans diminuent de 15 % les capacités cognitives d’un enfant, sans compter l’absentéisme causé par la maladie « , constate Iday, un réseau d’associations africaines basé en Belgique. L’OMS recense chaque année plus de 200 millions de cas de malaria et environ 500 000 décès, en majorité des enfants. Au total, près de 100 pays sont touchés. Mais l’essentiel de la charge est supportée par l’Afrique, où surviennent 90 % des infections et des décès. Les pertes économiques y sont estimées à 10 milliards de dollars par an, soit une réduction annuelle de croissance de 1,5 % du PIB africain. Pour Guy Mergeai, chercheur et professeur d’agronomie tropicale à Gembloux (ULiège),  » la malaria pèse lourdement sur le développement du continent.  »
Certes, le taux de mortalité de cette pathologie a reculé de près de 30 % depuis 2010. On constate néanmoins une recrudescence d’épidémies dans plusieurs pays d’Afrique, dont le Bénin, le Burundi, la RDC, le Kenya… L’OMS parle même de catastrophe sanitaire. Depuis peu, l’agence onusienne s’intéresse aux vertus thérapeutiques de la médecine traditionnelle. Toutefois, elle a  » prié instamment  » les autorités des pays touchés par la malaria de cesser la production et la commercialisation de feuilles d’artemisia, et cela au nom du principe de précaution.
Résistance aux médicaments
Si l’OMS ne cautionne pas l’utilisation de la plante comme moyen antipaludique, c’est de peur qu’apparaissent dans les populations du Sud des résistances aux ACT, médicaments composés d’artemisinine – une substance qui provient de la plante – et d’autres molécules dont dispose l’industrie pharmaceutique. Depuis 2001, l’agence de l’ONU impose les ACT comme remède de première ligne en Afrique. Ce qui n’étonne pas le Colombien German Velasquez, ancien directeur à l’OMS, devenu la bête noire des lobbies pharmaceutiques. Selon lui, l’agence est de plus en plus dépendante du secteur privé : en vingt-cinq ans, la part du budget de l’OMS provenant des Etats membres est passée de plus de 50 % à moins de 20 %.
Pour Pierre Lutgen, docteur en sciences et fondateur d’une ONG de Luxembourg qui promeut l’usage des plantes médicinales, l’argument selon lequel l’utilisation de l’artemisia annua pourrait générer des souches résistantes aux médicaments ACT ne tient pas.  » C’est le contraire qui se produit, explique-t-il : les doses massives d’artemisinine contenues dans les ACT peuvent entraîner un phénomène d’adaptation et de mutation. Des résistances incontrôlables aux ACT se développent dans le Sud-Est asiatique et atteignent désormais une dizaine de pays africains.  »
Quelle efficacité ?
L’OMS reproche aussi à la plante de ne pas contenir suffisamment d’artemisinine pour être efficace.  » Faux ! réplique Nathalie Schots, d’Iday : lorsque les plants d’artemisia annua comportent peu d’artemisinine, ils sont plus riches en flavonoïdes et autres éléments antipaludiques.  » En clair, on s’aperçoit que les différents composants de la plante ont une action antipaludique renforcée lorsqu’ils sont pris tous ensemble, comme c’est le cas dans la tisane ou la poudre de feuilles séchées.  » La « variété » artemisia afra, elle, ne contient pas d’artemisinine du tout et s’avère pourtant encore plus efficace que l’artemisia annua contre la malaria « , remarque le professeur Guy Mergeai, l’enseignant chercheur chez Gembloux Agro-Bio Tech.
La plante contiendrait-elle des substances dangereuses, comme certains l’insinuent ?  » Même à dose élevée, personne n’a pu constater un quelconque effet toxique aigu ou chronique, assure Pierre Lutgen. L’artemisia annua est d’ailleurs autorisée dans de nombreux pays, dont l’Allemagne, le Luxembourg, les Etats-Unis, l’Australie, la Chine, l’Afrique du Sud…  » En revanche, en Belgique, elle figure sur la liste des plantes dangereuses. Son commerce est interdit. En France aussi, on ne peut s’en procurer ni en pharmacie, ni en herboristerie.
Les moustiques s’adaptent
Si l’artemisia suscite un intérêt croissant au sein des ministères de la santé des pays du Sud, c’est parce cette plante médicinale apparaît comme un remède à la portée des populations locales : son prix est environ six fois inférieur à celui des médicaments recommandés. C’est aussi parce que les programmes officiels antimalaria butent sur plusieurs obstacles. Ainsi, l’OMS continue à distribuer des moustiquaires imprégnées d’insecticide, alors que les moustiques se sont adaptés : ils commencent à piquer plus tôt en journée ! Par ailleurs, outre la résistance du parasite aux médicaments déjà signalée, il y a le fait que la moitié environ des médicaments antipaludiques vendus en Afrique sont des contrefaçons, parfois dangereuses.
Certes, un vaccin antipaludique est attendu pour 2018. GSK, le géant pharmaceutique implanté à Wavre et Rixensart, y travaille depuis trente-trois ans ! Mais ce vaccin s’avère décevant : il ne serait efficace que dans 30 % des cas. En fait, il existe déjà un  » vaccin « , naturel et bon marché celui-là, assurent les proartemisia : des essais cliniques en Ouganda, au Kenya et en RDC montreraient que la prise de deux ou trois tasses de tisane d’armoise par semaine réduit le risque de paludisme de 80 %. De quoi inciter l’OMS à changer sa politique ?
Malaria Business, un film écrit et réalisé par Bernard Crutzen, commenté par Juliette Binoche.
PAR OLIVIER ROGEAU

Publicités

2017 malaria outbreaks in Africa

août 20, 2017

The 2017 malaria avalanche

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April 2, 2017 – 19:29 — Pierre Lutgen
Bigpharma-WHO-Gates desperately try to ignore peer reviewed scientific papers documenting the spread of ACT resistance in at least 12 African countries (see “Artemisinin resistance In Africa” http://www.malariaworld.org).

Several medical teams in Africa have demonstrated in randomized, double blind clinical trials that Artemisia infusions are powerful in therapy and prophylaxis (see “Breaking news from clinical trials with Artemisia plants” http://www.malariaworld.org).

How long will the business and genocide with nets, pills and dubious vaccines last, before WHO authorizes the therapy with herbal Artemisia?

ZIMBABWE THE MALARIA CASES SURGE (Abigal Mwonde in The Herald, April 1. 2017).

The country has recorded a significant increase in malaria cases compared to the same period in the last two years according to the Ministry of Health. Dr Mberkunashe said 119 593 cases were recorded in the first 11 weeks of this year compared to 73 019 and 82 328 cases for the same periods in 2016 and 2015.

ALARMING RECRUDESCENCE IN NAMIBIA (Alvin Kapitako, New Era. Mar 29, 2017)

“Unfortunately, a resurgence occurred over the past three years with 24 682 cases reported in 2016, and 87 people succumbed to the disease,” said Haufiku. The minister added: “As evidenced by the outbreaks observed in 2014, 2016 and 2017, Namibia remains at risk for malaria epidemics and resurgence.” Ironically significant progress was made towards the goal of eradicating malaria with a 96 percent reduction in cases and deaths since 2001.

MALARIA IN 20 DISTRICTS, SPREADING AT ALARMING RATE (Deccan Chronicle. Apr 1, 2017),

While malaria was confined to Udupi and Dakshina Kannada in the past, it has now spread to eight districts of North Karnataka. Alarmed at the rate at which malaria is spreading in the state, the government is preparing to tackle it on a war footing. While malaria was confined to Udupi and Dakshina Kannada in the past, it has now spread to eight districts of North Karnataka and sporadic cases are being reported from another 12 districts, according to Secretary, Health and Family Welfare, Shalini Rajaneesh. “Malaria is now found in around 20 districts of the state and is spreading at an alarming rate,” she told reporters here.

BURUNDI MALARIA OUTBREAK KILLS OVER 4000 THIS YEAR (Rodney Muhumuza in Washington Post. March 29)

An outbreak of malaria has killed over 4,000 people in Burundi so far this year, the United Nations said Wednesday, a dramatic rise over the 700 victims the government announced just two weeks ago. There have been over 9 million cases of malaria in the East African nation since January 2016, according to the report by the U.N. humanitarian office. Burundi, one of the world’s poorest countries, has a population of about 11 million. The malaria cases are “well beyond the epidemic threshold,” the report said, citing World Health Organization investigators.

NIGERIA: 10 000 MALARIA, MENINGITIS PATIENTS IN 9 DAYS (Damilola Akinola, Nigerian Tribune April 2)

Sokoto State Government says it has treated no fewer than 10,000 meningitis and malaria patients since March 20 following the high alert in the state health sector. The state Commissioner for Health, Dr Balarabe Kakale, made this known to the News Agency of Nigeria (NAN) on Wednesday in Sokoto. They were treated of mixed cases of meningitis and malaria with some pockets of other minor ailments.

BOTSWANA: LEADERSHIP TACKELS MALARIA OUTBREAK (E Mmolai, Daily News Mar 27)

As a mitigating measure to the Malaria outbreak, North West leadership has agreed to embark on a massive indoor residual re-spraying exercise in the district. This comes after an announcement by health officials that the district was hard hit by the epidemic as currently it recorded 794 cases of Malaria and five deaths in the highly affected region.

PRETORIA: THE TRUTH ABOUT MALARIA OUTBREAK (Theto Mahlangu, The Citizen Mar 23)

The department recently distributed pamphlets, urging residents to, among other things, stay indoors between sunset and sunrise, or wear long pants, socks and shirts with long sleeves when they have to go outside. Other precautionary measures include to keep windows and doors closed before dark.

IN COLOMBIA; ECUADOR THE INCREASING TREND OF MALARIA CASES CONTNUED IN 2016,

Eight of the 21 endemic countries (the Bolivarian Republic of Venezuela, Colombia, the Dominican Republic, Ecuador, Guatemala, Honduras, Nicaragua, and Peru) reported an increase in cases compared to the previous year.According to a new Pan American Health Organization Epidemiological Alert this week, UN health officials are reporting an increase in malaria transmission in certain areas of this region in 2016, including an increase in the most serious strain of the mosquito borne parasite, Plasmodium falciparum.In summary a 16% increase compared to the cases reported in 2014

MALARIA RAISE IN RWANDA

According to 2016 WHO report « In November 2016 we registered nearly 700,000 cases countrywide. We also noticed the resistance to insecticide, » Aimable Mbiturumuremyi, an official at Rwanda’s Health Ministry stated

ANGOLA: MALARIA DEATHS RISING Reporting by Herculano Coroado;

« This new malaria outbreak has devastated the entire country, even in provinces that have low endemic prevalence we are seeing the spread and surge in cases, » the WHO’s Angola representative Hernando Agudelo Ospina said.

MALARIA EPIDEMIC OUTBREAKS IN RDCONGO Célestin N. Nsibu, Reference: MWJ2015, 6, 11 part I: cross-sectional survey in Mweka District A series of fever outbreaks has previously been reported in the DR Congo

MALAWI GOVERNEMENT IS FACING MALARIA CHALLENGE

Nyassa Times, Zawadi Chilunga, Mar 15 2017 Malawi government is facing challenges to fight malaria that kills many people every day, with the news about the acute shortage of anti-malarial drugs in the countr. Ministry of Health spokesperson Adrian Chikumbe confirmed that public health facilities have run out of the essential drugs such as Lumerfantrine Artemether commonly known as LA.Venezuela: cases of malaria surge 76%

TANZANIA: MALARIA SEEN ESCALATING

Dodoma — The government has released a statement to mark « Universal Malaria Day » that indicates that the current infection rate status in the country is worse compared to the situation that prevailed in the past five years.

According to a press release given out in Dodoma yesterday by the Minister for Health, Community Development, Gender, Elders and Children, Ms Ummy Mwalimu the infection rate this year has reached 14.8 per cent compared to 10 per cent in the year 2012.

MALARIA OUTBREAK IN MADAGASCAR

The surprise here was to observe one in a zone of high transmission where people are supposed to have developed immunity.

In COLOMBIA, ECUADOR, VENEZUELA the increasing trend of malaria cases continued in 2016.

In 2015, eight of the 21 endemic countries (the Bolivarian Republic of Venezuela, Colombia, the Dominican Republic, Ecuador, Guatemala, Honduras, Nicaragua, and Peru) reported an increase in cases compared to the previous year.According to a new Pan American Health Organization Epidemiological Alert this week, UN health officials are reporting an increase in malaria transmission in certain areas of this region in 2016, including an increase in the most serious strain of the mosquito borne parasite, Plasmodium falciparum.In summary a 16% increase compared to the cases reported in 2014.

IN LIMPOPO S.A. MALARIA CASES RISE 50%

Malaria remains a serious public health threat as it could easily rebound, the NICD’s deputy director, Lucille Blumberg, warned on 02 May 2017.

Recent papers indeed ring alarm bells

Plasmodium chabaudi malaria parasites through a step-wise increase in artesunate dose evolve extremely rapidly slow clearance rates. These slower clearance rates provide fitness advantages to the parasite through increased overall density, recrudescence after treatment and increased transmission potential. Removal of only the susceptible parasites by artesunate treatment led to substantial increases in the densities of resistant parasites.

LC Pollitt, S Huijben, A Read, Rapid response to selection and increased transmission potential in artesunate-selected Plasmodium parasites, PloS Pathogens 2014, 10,4, e1004019.

The same research team found that mixed infections also are frequent in the mosquito. Mixed strains are obtained after multiple infective bites and accumulate in the mosquito and increase malaria transmission to the vertebrate host, with implications for the evolution of the parasite virulence and the spread of drug resistant strains

LC Pollitt, A Read, Existing infection facilitates establishment and density of malaria parasites in the mosquito vector. PLOS Pathogens, 2015, e1005003

CAPE VERDE: ‘Sudden and unprecedented increase’ in malaria in 2017

SOUTH SUDAN : Over 4,000 people have died from Malaria in the past six months. (AFP)

The Malaria disease is spread in an “unprecedented” level in South Sudan, killing thousands in the past six months, revealed an official in the health ministry. Isaac Maber told Asharq Al-Awsat that at least 4,000 people have died from Malaria since February, with over 900,000 also being infected.

Artemisia afra cures Buruli ulcer with high efficacy. Possible role of gallium.

juillet 15, 2017

Following up on same encouraging earlier trials, we launched with our African partners and the French association M4L larger scale clinical trials. The results obtained in these trials are extraordinary.
The trials were run in the Maniema province of RDC and were coordinated by Dr Jerome Munyangi who has alrready run the very successfull clinical trials with Artemisia plants against malaria, tuberculosis and bilharzia. The treatment consisted in the administration per os of an Artemisia afra decoction during 14 days and the application of a poultice containing an Artemisia afra extract during 28 days. These produces were from » Mother Nature » in Burundi. 21 patients completed the full treatment, some others were lost from sight. Those who took the complete treatment were totally cured, without any need
for surgical intervention. No remanent limitation in movements or other sequelae were noticed as it often happens after antibiotic treatment. Mycobacteria were counted under the microscope by the Ziehl-Neelsen method. No remaining mycobacteria could be detected after the treatment.

RTS vaccines: 20 years of false hopes

juin 14, 2017

The first results of the RTS,S vaccine already appeared in 1998 in a scientific paper. The conclusion was: Immune responses did not correlate with protection. Further optimization in vaccine composition will be required to induce longer-lasting protective immunity.
Stoute JA, Kester KE, Ballou Wr. Long-term efficacy and immune
responses following immunization with the RTS,S malaria vaccine.
J Infect Dis. 1998 178(4), 1139-44

Another randomised trial of the efficacy of RTS,S against natural P. falciparum infection in semi-immune adult men was run in The Gambia in 2001. Vaccine efficacy, adjusted for confounders, was 34%. Protection seemed to wane: estimated efficacy during the first 9 weeks of follow-up was 71% (46-85), but decreased to 0% (-52 to 34) in the last 6 weeks.
Bojang KA, Milligan PJ, RTS, S Malaria Vaccine Trial Team
Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium
falciparum infection in semi-immune adult men in The Gambia: a
randomised trial. Lancet. 2001 Dec 8;358(9297):1927-34

In a trial of 2008, the rate of efficacy against the more clinically relevant end point of clinical malaria in children 1 to 4 years of age was 30%
Philip Bejon, John Lusingu, Ally Olotu., Efficacy of RTS,S/AS01E
Vaccine against Malaria in Children 5 to 17 Months of Age. NEJM
2008, 359, 2521-39

In 2009 vaccine efficacy over the 45-month surveillance period against a first or only episode of clinical malaria disease was 30.5% and the VE against all episodes was 25.6%
Sacarlal J, Alonso PL. Long-term safety and efficacy of the
RTS,S/AS02A malaria vaccine in Mozambican children. J Infect Dis.
2009 Aug 1;200(3):329-36. doi: 10.1086/600119.

In 2013 6,537 infants aged 6–12 wk and 8,923 children aged 5–17 mo were randomized to receive three doses of RTS,S/AS01. Vaccine efficiency against clinical malaria in infants was 27%, with no significant protection against severe malaria, malaria hospitalization, or all-cause hospitalization
Sanjeev Krishna, Academic Editor. Efficacy and Safety of the
RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A
Phase 3 Randomized, Controlled Trial in Children and Young
Infants at 11 African Sites. PLoS Med. 2014 Jul; 11(7):
e1001685.

To continuously raise false hopes by massive press releases is immoral. Who pays for all these guinea pigs: Bill Gates or GSK Wavre?

La torture est légale aux Etats-Unis

mai 6, 2017

Extrait du livre de Tzvetan Tadorov. Les ennemis de la liberté, ed Robert Laffont 2012.
Abu Ghraib et Guantanamo ne sont pas des exceptions. Une publication officielle du gouvernement américain, datée d’avril 2009 sous Obama, a révélé la réglementation extrêmement tâtillonne de la torture, formulée dans les manuels de la CIA et reprise à leur compte par les responsables juridiques du gouvernement. Car telle est la nouveauté: la torture n’est plus présentée comme une infraction, regrettable, mais excusable. Elle est la norme même. On pouvait s’imaginer jusque-là que les pratiques de torture relevaient de ce qu’on appelée des bavures, dépassements involontaires des limites, provoqués par l’urgence du moment. On s’est aperçu au contraire qu’il s’agissait de procédures fixées dans les moindres détails, au centimètre et à la seconde près.
Ainsi les formes de tortures retenues sont-elles au nombre de dix, chiffre qui monte ensuite à treize. Elles sont reparties en trois catégories, dont chacune connaît plusieurs degrés d’intensité: préparatoires (nudité, alimentation manipulée, privation de sommeil), correctives (les coups) et coercitives (arrosage d’eau enfermement dans des boîtes, supplice de la baignoire). Pour les gifles, l’interrogateur doit frapper avec les doigts écartés, à égale distance entre l’extrémité du menton et le bas du lobe de l’oreille. L’arrosage d’eau du prisonnier nu peut durer vingt minutes si l’eau est à 5 degrés, quarante si elle est à 10 degrés et jusqu’à soixante si elle est à 15 degrés. Les privations de sommeil ne doivent pas dépasser quatre-vingts heures, mais après un repos de huit heures, elles peuvent recommencer. L’immersion dans la baignoire peut durer jusqu’à douze secondes, pas plus de deux heures par jour, pendant trente jours consécutifs. Un prisonnier particulièrement coriace a subi ce supplice à 183 reprises en mars 2003. L’enfermement dans une petite boîte ne doit pas dépasser deux heures, mais si la boîte permet au prisonnier de se tenir debout, on peut aller jusque huit heures de suite.
La contagion se répand bien au-delà du cercle limité des tortionnaires: plusieurs autres groupes de professionnels sont impliqués dans la pratique des supplices. Des conseillers juridiques du gouvernement sont là pour assurer l’impunité légale de leurs collègues et fournir une légitimation à leurs actes. Sont régulièrement présents des psychologies, des psychiatres, des médecins, des femmes (les tortionnaires sont des hommes, mais l’avilissement sous le regard des femmes aggrave l’humiliation). Pendant ce temps, des professeurs d’université produisent des justifications morales, légales et philosophiques de la torture. La torture marque de manière indélébile les torturés, mais elle corrompt aussi l’esprit des tortionnaires. De proche en proche la société entière se trouve atteinte par ce cancer. Un Etat qui légalise la torture n’est plus une démocratie.

Artemisias stronger than vaccines

mai 5, 2017

Tuesday, May 02, 2017 by: Tracey Watson

(Natural News) Though malaria is a virtually unknown disease to many in the U.S., it is a global menace that affects upwards of 212 million people annually, killing close to half a million in any given year. In the past, the medical approach to the treatment of malaria has been to prescribe a type of drug called Artemisinin Combination Therapies (ACTs). However, on the eve of World Malaria Day – which falls on the 25th of April each year – the World Health Organization (WHO) announced that it will be starting to test a new anti-malaria vaccine in the fields of Kenya, Ghana and Malawi, beginning in 2018. Though scientists involved with the development of the vaccine have called this “great news,” insisting it will “make a real difference,” is this vaccine really necessary, and will it live up to the hype? ………..
One wonders, therefore, why there is so much interest in developing an anti-malaria vaccine now, when the battle is clearly already being won. Very disturbing, too, is the fact that the Bill and Melinda Gates Foundation (BMGF) has been actively involved in the development of this vaccine, known as Mosquirix or RTS,S.
Granted, there has been a marked increase in the number of drug-resistant malaria cases worldwide, but that doesn’t mean a preventative vaccine is the best solution. Even if it doesn’t kill you – and who knows, when the BMGF is involved – vaccines have side effects and are not 100 percent effective. And there is a naturally available treatment that has been successfully used to treat malaria in traditional Amazonian, Chinese and African medicine for centuries, that doesn’t have side effects, can be grown anywhere and can even treat drug-resistant malaria: The Artemisia annua plant, commonly known as sweet wormwood or sweet annie.
The Health Ranger recently reported on a study published in the journal Phytomedicine, which describes how the Artemisia annua plant saved 18 patients in the Congo who were suffering from drug-resistant malaria that was totally unresponsive to any western medical treatment. When the patients failed to respond to ACTs, doctors tried the dried leaves of the Artemisia annua plant in a final bid to save their patients’ lives. After only five days of treatment, all 18 patients were 100 percent recovered, and blood tests revealed absolutely no remaining parasites in their blood.
If a naturally occurring, freely available plant medicine is available to treat drug-resistant strains of malaria, and other preventative measures have already turned the tide in the fight against this disease, any thinking person has to wonder why the BMGF, the WHO and others are suddenly pushing for the release of this new vaccine.

A new worldwide malaria outbreak

avril 17, 2017

A new worldwide malaria outbreak

Bigpharma-WHO-Gates desperately try to ignore peer reviewed scientific papers documenting the spread of ACT resistance in at least 12 African countries (see “Artemisinin resistance In Africa” http://www.malariaworld.org).
Several medical teams in Africa have demonstrated in randomized, double blind clinical trials that Artemisia infusions are powerful in therapy and prophylaxis (see “Breaking news from clinical trials with Artemisia plants” http://www.malariaworld.org)
How long will the business and genocide with nets, pills and dubious vaccines last, before WHO authorizes the therapy with herbal Artemisia?

ZIMBABWE THE MALARIA CASES SURGE (Abigal Mwonde in The Herald, April 1. 2017).
The country has recorded a significant increase in malaria cases compared to the same period in the last two years according to the Ministry of Health. Dr Mberkunashe said 119 593 cases were recorded in the first 11 weeks of this year compared to 73 019 and 82 328 cases for the same periods in 2016 and 2015.
ALARMING RECRUDESCENCE IN NAMIBIA (Alvin Kapitako, New Era. Mar 29, 2017)
“Unfortunately, a resurgence occurred over the past three years with 24 682 cases reported in 2016, and 87 people succumbed to the disease,” said Haufiku. The minister added: “As evidenced by the outbreaks observed in 2014, 2016 and 2017, Namibia remains at risk for malaria epidemics and resurgence.” Ironically significant progress was made towards the goal of eradicating malaria with a 96 percent reduction in cases and deaths since 2001.
MALARIA IN 20 DISTRICTS, SPREADING AT ALARMING RATE (Deccan Chronicle. Apr 1, 2017),
While malaria was confined to Udupi and Dakshina Kannada in the past, it has now spread to eight districts of North Karnataka. Alarmed at the rate at which malaria is spreading in the state, the government is preparing to tackle it on a war footing. While malaria was confined to Udupi and Dakshina Kannada in the past, it has now spread to eight districts of North Karnataka and sporadic cases are being reported from another 12 districts, according to Secretary, Health and Family Welfare, Shalini Rajaneesh. “Malaria is now found in around 20 districts of the state and is spreading at an alarming rate,” she told reporters here.
BURUNDI MALARIA OUTBREAK KILLS OVER 4000 THIS YEAR (Rodney Muhumuza in Washington Post. March 29)
An outbreak of malaria has killed over 4,000 people in Burundi so far this year, the United Nations said Wednesday, a dramatic rise over the 700 victims the government announced just two weeks ago. There have been over 9 million cases of malaria in the East African nation since January 2016, according to the report by the U.N. humanitarian office. Burundi, one of the world’s poorest countries, has a population of about 11 million. The malaria cases are “well beyond the epidemic threshold,” the report said, citing World Health Organization investigators.
NIGERIA: 10 000 MALARIA, MENINGITIS PATIENTS IN 9 DAYS (Damilola Akinola, Nigerian Tribune April 2)
SOKOTO State Government says it has treated no fewer than 10,000 meningitis and malaria patients since March 20 following the high alert in the state health sector. The state Commissioner for Health, Dr Balarabe Kakale, made this known to the News Agency of Nigeria (NAN) on Wednesday in Sokoto. They were treated of mixed cases of meningitis and malaria with some pockets of other minor ailments.
BOTSWANA: LEADERSHIP TACKELS MALARIA OUTBREAK (E Mmolai, Daily News Mar 27)
As a mitigating measure to the Malaria outbreak, North West leadership has agreed to embark on a massive indoor residual re-spraying exercise in the district. This comes after an announcement by health officials that the district was hard hit by the epidemic as currently it recorded 794 cases of Malaria and five deaths in the highly affected region.
PRETORIA: THE TRUTH ABOUT MALARIA OUTBREAK (Theto Mahlangu, The Citizen Mar 23)
The department recently distributed pamphlets, urging residents to, among other things, stay indoors between sunset and sunrise, or wear long pants, socks and shirts with long sleeves when they have to go outside. Other precautionary measures include to keep windows and doors closed before dark being Okavango.
MALARIA ON THE RAISE IN RWANDA.
According to 2016 WHO report « In November 2016 we registered nearly 700,000 cases countrywide. We also noticed the resistance to insecticide, » Aimable Mbiturumuremyi, an official at Rwanda’s Health Ministry stated
ANGOLA: MALARIA DEATHS RISING (Reporting by Herculano Coroado)
« This new malaria outbreak has devastated the entire country, even in provinces that have low endemic prevalence we are seeing the spread and surge in cases, » the WHO’s Angola representative Hernando Agudelo Ospina said.
THE MALARIA CRISIS INDIA DOESN’T WANT TO AKNOWLEDGE (Ankita Rao & Vivekananda Nemana)
An investigation shows routine manipulation of data, shortages of supplies, understaffing and enduring dysfunction. The wide gulf between India’s official record of 1,018 deaths and The Lancet estimate of 46,800 is causing some to worry that bad data are keeping resources from reaching the people who need them most.
In COLOMBIA, ECUADOR, VENEZUELA the increasing trend of malaria cases continued in 2016.
In 2015, eight of the 21 endemic countries (the Bolivarian Republic of Venezuela, Colombia, the Dominican Republic, Ecuador, Guatemala, Honduras, Nicaragua, and Peru) reported an increase in cases compared to the previous year.According to a new Pan American Health Organization Epidemiological Alert this week, UN health officials are reporting an increase in malaria transmission in certain areas of this region in 2016, including an increase in the most serious strain of the mosquito borne parasite, Plasmodium falciparum.In summary a 16% increase compared to the cases reported in 2014.
MALARIA EPIDEMIC OUTBREAKS IN RDCONGO
Célestin N. Nsibu, Reference: MWJ2015, 6, 11 part I: cross-sectional survey in Mweka District
A series of fever outbreaks has previously been reported in the DR Congo
MALAWI GOVERNEMENT IS FACING MALARIA CHALLENGE (Nyassa Times, Zawadi Chilunga, Mar 15 2017)
Malawi government is facing challenges to fight malaria that kills many people every day, with the news about the acute shortage of anti-malarial drugs in the countr. Ministry of Health spokesperson Adrian Chikumbe confirmed that public health facilities have run out of the essential drugs such as Lumefantrine Artemether commonly known as LA.
MALARIA OUTBREAK IN KENYA
“We started seeing an increase of people admitted with malaria last month, but we may not really know what caused it,” said Dr Philip Muthoka of the department of disease surveillance and response.
Between March 6 and March 27, 112 cases have been reported from Turbo alone,” Dr Muthoka added.
“We started seeing an increase of people admitted with malaria last month, but we may not really know what caused it,” said Dr Philip Muthoka of the department of disease surveillance and response.
He said the increase in malaria cases has been reported only in Turbo sub-county. “Other counties are below the alert line, so there is no cause for alarm. Between March 6 and March 27, 112 cases have been reported from Turbo alone,” Dr Muthoka added.

Un second massacre au Burundi

février 7, 2017

ecrit par Emile Schmitz

Le coupable: non pas la race ou la religion, mais le dollar.

En dépit des cris de victoire de l’OMS proclamant chaque année une chute spectaculaire du paludisme certains pays sont hélas confrontés à une recrudescence catastrophique. Tel est le cas du Burundi.
Le pays a rapporté 4 716 152 cas en 2014 et 7 813 958 cas en 2016. Une mission d’urgence de l’OMS a confirmé cette flambée dans un rapport du 1er février. Le plus alarmant est qu’elle confesse un échec flagrant des techniques mises en oeuvre. Une distribution massive de moustiquaires (MILDA) en 2014 avait provoqué une baisse momentanée des cas. Cet effet fut de courte durée et comme dans d’autres pays africains cette distribution a souvent augmenté plutôt que diminué l’incidence. Cet effet est fort inquiétant et peut avoir plusieurs causes:
– de nombreuses études scientifiques ont montré que les moustiques deviennent de plus en plus résistants aux pyrethroides d’imprégnation. Et ces moustiques plus résistants sont plus virulents, plus efficaces pour la transmission.
– les pyrethroides comme d’autres insecticides affaiblissent le système immunitaire des enfants, premières victimes du paludisme.

La Ministre de la Santé du Burundi ne peut pas plaider l’innocence.
La mission de l’OMS ne manque pas de la critiquer vertement en constatant qu’elle a manqué de réaliser et de déclarer cette flambée, limitant ainsi les possibilités d’assistance internationale. Elle ne peut pas ignorer que dans les pays de la région un remède des plus efficaces est mis en œuvre contre le fléau: la tisane d’Artemisia. Et cela avec l’appui et l’encouragement des autorités sanitaires, des Ministères de la Santé et même de l’OMS-Afro. En Tanzanie, au Kenya, en Ouganda, en RDCongo, en Afrique du Sud et dans au moins six autres pays africains. Et la plante la plus efficace s’avère être une plante africaine, l’Artemisia afra, autant et plus que la variété chinoise Artemisia annua.

Le Ministère de la Santé du Burundi semble tout faire pour que cette thérapie ne soit pas connue. En 2014 une équipe d’experts universitaires internationaux qui venaient au Burundi pour en parler ont vu leur conférence interdite par ce même Ministère. Et pourtant des plantations de Artemisia annua et afra existent au Burundi depuis dix ans grâce à Hannelore Klabes. On sait aujourd’hui que c’est sur injonction de Bigpharma, de l’OMS, de MSF et de l’Institut des Maladies Tropicales et Coloniales d’Anvers que la conférence était interdite. On sait aussi que certaines de ces organisations gagnent jusque 6% sur chaque pilule ACT vendue en Afrique.
Il y a aussi l’énorme lobby des moustiquaires ou UNCEF, Bill & Melinda, USAID et Global Fund sont les distributeurs/vendeurs attitrés. Le marché du paludisme en Afrique et les bénéfices qui en découlent sont colossaux. De l’argent sale entaché de sang.
Le Burundi a reçu cette année $32 195 135 pour l’achat de MILDA et d’ACT.
En absence de toute autre approche approuvée par les financiers du Nord, la mission de l’OMS recommande d’augmenter la distribution de moustiquaires (sic) avec un nouveau subside de $36 000 000. Les ACT ont presque disparu du marché à l’exception des falsifications. Les ACT ont donné des résistances non seulement au Cambodge mais également dans une dizaine de pays africains, selon des études scientifiques publiées. Un génocide programmé.
Et pourtant des essais cliniques récents sur un millier de patients impaludés au Maniema voisin ont montré que l’infusion d’Artemisia est beaucoup plus efficace que les pilules ACT-ASAQ, et sans effets secondaires, sans recrudescence. En effet au 28e jour il n’y a plus de parasites ni même de gamétocytes dans le sang. Cette absence de gamétocytes a été confirmée dans un essai de prophylaxie récent avec 200 enfants dans deux écoles de la même province congolaise. Après un mois de traitement de trois tasses d’infusion par semaine une absence totale de paludisme a été observée chez ces enfants. On peut donc, non seulement guérir ou prévenir le paludisme avec cette plante, mais également enrayer la transmission au moustique. Oui, éradiquer ce fléau.
L’Artemisia afra est une plante pérenne ne contenant pas d’artemisine et utilisée depuis des générations contre la malaria et d’autres maladies, donc selon les règles mêmes de l’OMS et la FAO automatiquement qualifiée comme plante médicinale et complément alimentaire dans ces pays africains.
Ce sont de courageux médecins de plusieurs pays africains qui ont développé et démontré cette approche révolutionnaire.
Comme Kenyatta, Nkrumah, Lumumba, Mandela, ont conquis l’indépendance politique, eux
entreront dans l’histoire comme vainqueurs du néocolonialisme de BigpharmaOMS et de ses laquais basanés.

Émile Schmitz Athus

Artemisia afra clinical trials: malaria, tuberculosis, bilharzia

novembre 13, 2016

Jérôme Munyangi, Maniema, RDCongo, Lucile Cornet-Vernet, M4L France, Pierre Lutgen, IFBV-BELHERB, Luxembourg,
Contact: lutgenp@gms.lu
Since 9 years the association IFBV-BELHERB from Luxembourg has established a working relationship with African and South American universities, in close cooperation with other European research institutions. Several of these partners have run clinical trials with Artemisia annua tea. In all these trials a therapeutical effect of 95 % or higher was confirmed by the use over 7 days of whole leaf infusion [1], [2], [3], [4] capsules or tablets. One of the surprising effects noticed in these trials was that that the artemisinin content had very little impact on the results. This lead us to make an analysis as complete as possible of all the constituents, organic and inorganic, in a large series of Artemisia annua samples from different origins [5]. The effect of polysaccharides, amino acids, polyunsaturated fatty acids, pentacyclic triterpenes, cumarins, phytosterols and saponins has been neglected in the past [6]. Several papers have shown that A. annua ingested as powdered leaves or in conjunction with fatty food significantly increases the artemisinin concentration in the blood and even overcomes resistance to artemisinin [7]. It is well documented in the literature that A. afra or sieberi which contain little or no artemisinin are extensively used as antimalarials. They contain at least 5 molecules of the same antimalarial efficacy as artemisinin. Recent research from the Al Quds University has shown that aqueous infusions of several Artemisia species strongly inhibit beta-hematin, like chloroquine did [8]. But the most important finding in several of the clinical trials, especially in Kenya and Uganda, was that people who drink one or two cups of Artemisia annua tea per week become immune against malaria [9]. At Lubumbashi, RDCongo Dr C Kansango Tchandema has shown in 2014 that Artemisia annua and Artemisia afra raised CD4+[see2]. Anti-HIV properties of Artemisia afra have been documented by a team at the University of Leiden [10]. Strong prophylactic results have been obtained with ARTAVOL, a mixture of herbs developed Dr Patrick Ogwang at the Ministry of Health . The produce does not contains Artemisia without artemisinin. In fact the antimalarial properties of Artemisia plants other than Artemisia annua are no surprise. The Chinese favoured Artemisia apiacea and the French in Algeria during 100 years protected their soldiers against malaria with Artemisia absinthium.
In 2015 [11] a team of medical doctors in RDCongo, Jerome Munyangi and Michel Idumbo, have run randomized clinical trials on a large scale in the Maniema province with the participation of some 1000 malaria infected patients. The trials were run in conformity with the WHO procedures and compared Artemisia annua and Artemisia afra with ACTs (Coartem and ASAQ). For all the parameters tested herbal treatment was significantly better than ACTs: faster clearance for fever and parasitemia, absence of parasites and gametocytes as confirmed by PCR on day 28 for 99.5% of the Artemisia treatments and 79.5% only for the ACT treatments. A total absence of side effects was evident for the treatments with the plants, but for the 498 patients treated with ACTs, 210 suffered from diarrhea, and/or nausea, pruritus, hypoglycemia etc. The efficiency was equivalent for Artemisia annua and Artemisia afra [see2]. More important even is the observation for the total absence of gametocytes after 7 days treatment with the herb. A tremendous hope for malaria eradication. The results have been communicated to the local health authorities, and to the Ministries of Health and Research in the RDCongo who were supportive of these trials. The draft of a paper is almost ready and will be submitted to a peer reviewed scientific journal.
In parallel with the clinical trials against malaria, (see Breaking News Jan. 5 on http://www.malariaworld.org) the same team has completed another large scale randomized, double blind trial against schistosomiasis, Artemisia vs Praziquantel. The results confirm previous anecdotic results from several countries in Africa. Both arms in this trial had 400 infected patients. The treatment efficiency was 97 % in the Artemisia arm and 71% in the Praziquantel arm. No side effects were noticed in the Artemisia treatment. Praziquantel caused vomiting in 26.5% of the patients, abdominal pain in 18.5%, cephalalgy in 15.5%. Very impressive is the fact that the Artemisia treatment led to an unexpected almost complete absence of eggs in feces after 2 months. Schistosomiasis kills 150 000 Africans per year and more than 70 000 000 are infected. A neglected disease in neglected, poor populations where the only existing drug, Praziquantel, loses efficiency year after year.
In 2016 clinical trials have been run against Tuberculosis and Buruli ulcer with Artemisia annua and Artemisia afra. Screening trials in 2015 had been promising and these recent large scale, randomized, double blind have resulted in an obvious therapeutic effect of these plants against Mycobacteria, not only tuberculosis but also Buruli ulcer. After three weeks of treatment the Ziehl stain assay is negative for alcohol-resistant bacteria. They will be published in the scientific literature. Most of us ignore that on Nov 3, 2015 a Convention was signed in Bali declaring the fight against the looming TB-Diabetes co-epidemic, one of the greatest global health challenges. An estimated two billion people, or one third of all people worldwide, live with a tuberculosis (TB) infection, of whom 9.6 million people develop active TB disease annually. TB is the leading cause of death worldwide due to a single infectious pathogen, responsible for 1.5 million human deaths in 2014, and 95 percent of human TB deaths occur in low- and middle-income countries. Diabetes mellitus is escalating worldwide. Clinical assays are planned to be run in the Katanga province of RDCongo with Artemisia plants against diabetes.
All these trials are run in compliance with the WHO protocol, full approval of the health authorities of the country and the province and encouragements of WHO-Afro.
References:
1.Chougouo Kengne RD, Kouamouo J, Moyou Somo R, Penge On Okoko, (2009). Comparative Study of the Quality and Efficiency of Artemisinin Drug Based and Artemisia annua grown in Cameroun, MIM conference, Nairobi, Kenya, 2 Nov 2009, MIM 15225512
2. Kansango Tchandema C, Lutgen P. (2016) In Vivo Trial on the Therapeutic Effects of Encapsulated Artemisia annua and Artemisia afra. Global Journal for Research Analysis, 5(6), 228-234
3.Gebeyaw T, Vigzaw 1,, Tegbar V. (2010), Use of the Plant Artemisia annua as Natural Anti-Malarial Herb in Arbaminch Town, Ethiop J Health Biomed Sc 2(2), 75-81
4. Zime-Diawara H, Ganfon H, Gbaguidi F, Yemoa A (2015), The antimalarial action of aqueous and hydro alcoholic extracts of Artemisia annua L. cultivated in Benin, Journal of Chemical and Pharmaceutical Research, 7(8): 817-823
5.Chougouo Kengne RD (2010) Rapport de Stage. Mise au Point et Validation des Procédures analytiques pour la Détermination de certains Composés de la Plante Artemisia annua, Université des Montagnes, Cameroon, Laboratoire National de la Santé, Luxembourg
6.Onimus M, Carteron S, Lutgen P (2013) The Surprising Efficiency of Artemisia annua Powder Capsules. Med Aromat Plants 2: 125. doi:10.4172/2167-0412.1000125
7. Elfawal M, Towler M, Reich NG, Weathers P and Rich S (2014) Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin. http://www.pnas.org/cgi/doi/10.1073/pnas.1413127112
8. Akkawi M, Suhair J, Ogwang PE, Lutgen P (2014), Investigations of Artemisia annua and Artemisia sieberi water extracts, Medicinal & Aromatic Plants 3:1, ISSN: 2167-0412
9. Ogwang PE, Ogwal JO. Kasasa S. Deogratius O, Obua C (2012) Artemisia annua L. Infusion consumed once a Week reduces Risk of multiple Episodes of Malaria: A randomised tTrial in an Ugandan Community, Trop J Pharm res 13(3) 445-453
10.Van der Kooy F. Artemisia annua and its Anti-HIV Activity (2014) T. Aftab et al. (eds.), Artemisia annua – Pharmacology and Biotechnology, DOI: 10.1007/978-3-642-41027-7_14, Springer-Verlag Berlin Heidelberg
11 This document is an abstract intended for fast disclosure. It is based on personal communications. Figures, graphs and references of the clinical trials will be included in the peer reviewed scientific papers to be published in the coming months..

Bali, tuberculosis, diabetes and Artemisia

août 18, 2016

Most of us ignore that on Nov 3, 2015 a Convention was signed in Bali declaring the fight against the looming TB-Diabetes co-epidemic, one of the greatest global health challenges.
An estimated two billion people, or one third of all people worldwide, live with a tuberculosis (TB) infection, of whom 9.6 million people develop active TB disease annually. TB is the leading cause of death worldwide due to a single infectious pathogen, responsible for 1.5 million human deaths in 2014, and 95 percent of human TB deaths occur in low- and middle-income countries.
Diabetes mellitus is escalating worldwide. More than half of people with diabetes are unaware of their condition as they have never been tested, and 84% of all undiagnosed cases live in low and middle income countries,
People with diabetes are two-to-three times more likely to develop TB when compared to people without diabetes. The excess vulnerability to TB disease in people with diabetes is mainly related to altered immune response to TB infection as a consequence of high blood sugar due to undiagnosed or poorly controlled diabetes.
A Lancet study in 2009 had confirmed the convergence of the two epidemics (KE Dooley et al. Lancet Infect Dis. 2009. 91, 737-746). In 1934 already this link had been discovered in Boston MA (H Root, N Eng J Med 1934, 210,78). In a study in Egypt, which compared 119 patients with treatment failure to 119 controls, diabetes conferred a 3 times increased risk of treatment failure (AM Morsy et al., East Meditter Health J. 2003, 9, 689-701). Two retrospective cohort studies of patients with pulmonary tuberculosis in Maryland, USA, have shown a 6.5 times increased risk of death in diabetes patients (KK Oursler et al., Clin Infect Dis 2002, 34, 752-59). It appears also that tuberculosis may lead to diabetes in those not previously known to be diabetic (GP Nichols, Am Rev Tuberc 1957 76, 1016-30).
Our associations IFBV-BELHERB from Luxembourg and M4L from Paris are involved in clinical trials with African partners to study the in vivo effect of Artemisia annua and Artemisia afra on these diseases. Screening trials in 2015 had been promising and recent large scale, randomized, double blind have resulted in an obvious therapeutic effect of these plants against Mycobacteria, not only tuberculosis but also Buruli ulcer. After three weeks of treatment the Ziehl stain assay is negative for alcohol-resistant bacteria.
These trials were run in the province of Maniema, RDC Congo, in accordance with the WHO protocol and ethical approval of the local health authorities. They will be published in the scientific literature.

Jerome Munyangi, Lucile Cornet-Vernet, Pierre Lutgen